- Title
- Autoantibodies are not predictive markers for the development of depressive symptoms in a population-based cohort of older adults
- Creator
- Iseme, R. A.; McEvoy, M.; Kelly, B.; Agnew, L.; Attia, J.; Walker, F. R.; Oldmeadow, C.; Boyle, M.
- Relation
- European Psychiatry Vol. 30, Issue 6, p. 694-700
- Publisher Link
- http://dx.doi.org/10.1016/j.eurpsy.2015.06.006
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2015
- Description
- Background: Autoantibodies have been implicated in the etiologic pathway of depressive disorders. Here, we determine the association between the presence of a panel of autoantibodies at baseline and change in depression symptom score over 5-year follow-up in a cohort of healthy elderly Australians. Methods: Serum samples from 2049 randomly selected subjects enrolled in the Hunter Community Study (HCS) aged 55-85 years were assayed for a range of autoimmune markers (anti-nuclear autoantibodies, extractable nuclear antigen autoantibodies, anti-neutrophil cytoplasmic autoantibodies, thyroid peroxidase autoantibodies, tissue transglutaminase autoantibodies, anti-cardiolipin autoantibodies, rheumatoid factor and cyclic citrullinated peptide autoantibodies) at baseline. Depression symptom score was assessed using the Centre for Epidemiological Study (CES-D) scale at baseline and 5 years later. Results: Autoantibody prevalence varied amongst our sample with ANA being the most prevalent; positive in 16% and borderline in 36% of study population. No evidence for a relationship was found between change in CES-D score over time and any autoimmune marker. Statins and high cholesterol were significantly associated with change in CES-D score over time in univariate analysis; however, these were probably confounded since they failed to remain significant following multivariable analysis. Conclusions: Autoantibodies were not associated with change in CES-D score over time. These findings point to an absence of autoimmune mechanisms in the general population or in moderate cases of depression.
- Subject
- autoantibodies; depression; autoimmunity; centre for epidemiological study; depression (CES-D) scale; depressive symptoms; autoimmune markers
- Identifier
- http://hdl.handle.net/1959.13/1332572
- Identifier
- uon:26897
- Identifier
- ISSN:1778-3585
- Language
- eng
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